Papel del ácido ursodesoxicólico en 40 años de tratamiento para la colangitis biliar primaria

Autores/as

  • Paola Andrea Montoya-Orozco Universidad de Antioquia
  • Ana Lizeth Moreno-Cuadros Universidad de Antioquia

DOI:

https://doi.org/10.59093/27112322.174

Palabras clave:

ácido ursodesoxicólico, colangitis biliar primaria, tratamiento, ácidos biliares, bilis.

Resumen

La colangitis biliar primaria es una enfermedad hepática autoinmune que conduce a la destrucción progresiva de los conductos biliares intrahepáticos, lo que aumenta el riesgo de desarrollar cirrosis e hipertensión portal. Actualmente, el ácido ursodesoxicólico es el medicamento de primera línea para el tratamiento de esta entidad. Este medicamento desplaza los ácidos biliares hidrofóbicos y aumenta las concentraciones de ácidos biliares hidrofílicos en la bilis, lo cual favorece la integridad de los conductos biliares, adicionalmente, tiene efectos antiinflamatorios y propiedades inmunomoduladoras y antiapoptóticas. En los últimos 40 años, numerosos ensayos clínicos han respaldado la eficacia clínica del ácido ursodesoxicólico y su seguridad cuando se utiliza en pacientes con colangitis biliar primaria. Se realiza una revisión del ácido ursodesoxicólico en el contexto de colangitis biliar primaria, se describe su historia, mecanismos de acción, efectos secundarios y dosificación. Finalmente, se menciona su uso en situaciones especiales como son el embarazo y la lactancia.

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Biografía del autor/a

Paola Andrea Montoya-Orozco, Universidad de Antioquia

Estudiante de Medicina. Grupo de Gastrohepatología, Universidad de Antioquia. Medellín, Colombia.

Ana Lizeth Moreno-Cuadros, Universidad de Antioquia

Estudiante de Medicina. Grupo de Gastrohepatología, Universidad de Antioquia. Medellín, Colombia.

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Publicado

2023-05-02

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Montoya-Orozco, P. A., & Moreno-Cuadros, A. L. (2023). Papel del ácido ursodesoxicólico en 40 años de tratamiento para la colangitis biliar primaria. Hepatología, 4(2), 152–164. https://doi.org/10.59093/27112322.174

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