Albúmina en cirrosis: perspectiva inflamatoria

Autores/as

DOI:

https://doi.org/10.59093/27112330.100

Palabras clave:

albúmina sérica humana, cirrosis hepática, falla hepática aguda sobre crónica, inflamación, ascitis.

Resumen

La albúmina sérica humana es la proteína más abundante en el plasma, su estructura molecular le confiere estabilidad, pero también flexibilidad para ligar y transportar un amplio rango de moléculas. Su función oncótica es la propiedad más reconocida que la lleva a introducirse en la terapéutica médica como un expansor de volumen. Sin embargo, en los últimos años se le han adicionado funciones con carácter antioxidante, inmunomodulador y de estabilización endotelial, que hacen presumir que su impacto terapéutico está más allá de sus funciones volumétricas. En los últimos años, específicamente en la cirrosis y la falla hepática aguda sobre crónica, se ha tenido un cambio en el paradigma fisiológico, desde una perspectiva netamente hemodinámica hacia una perspectiva inflamatoria, en donde las funciones oncóticas y no oncóticas de la albúmina están alteradas y tienen un carácter pronóstico en estas entidades. Este conocimiento creciente, desde una perspectiva inflamatoria, hace que se fortalezca el uso terapéutico de la albúmina sérica humana desde las indicaciones tradicionales como prevención de la disfunción circulatoria posparacentesis, prevención y tratamiento de lesión renal aguda, hasta las discusiones para administración a largo plazo en pacientes cirróticos con ascitis.

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Biografía del autor/a

Lina Paola Tovar-Díaz, Hospital Universitario San Vicente Fundación, Universidad de Antioquia

Médica, Especialista en Medicina Interna, Hospital Universitario San Vicente Fundación. Docente, Departamento de Medicina Interna, Universidad de Antioquia. Medellín, Colombia.

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Publicado

2024-01-02

Cómo citar

Tovar-Díaz, L. P. (2024). Albúmina en cirrosis: perspectiva inflamatoria. Hepatología, 5(1), 48–61. https://doi.org/10.59093/27112330.100

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