Hepatología is a medical and scientific journal published semiannually. Hepatología is the dissemination tool of the Colombian Association of Hepatology for scientific and technological advances in the area of Hepatology. Through the topics addressed in Hepatología, training and ongoing education is available to those interested in this branch of medicine, whether they are students or professionals.
The journal Hepatología publishes the knowledge and experiences of the members of the Colombian Association of Hepatology, undergraduate and graduate students of the different medical faculties in the country, Hepatology residents, and groups in public and private hospitals, among other professionals related to Hepatology, both in clinical and basic sciences.
Fontan-associated liver disease
Fontan surgery diverts the flow of the inferior vena cava through a cavopulmonary anastomosis, to avoid mixing the oxygenated and non-oxygenated blood, in the presence of tricuspid atresia associated with hypoplastic ventricle. The physiological changes produced by this new circulation have several consequences at cardiac and extracardiac level, including the liver, with multiple descriptions of chronic liver disease of vascular origin, and even hepatocellular carcinoma in cirrhotic liver at an early age.
Nonalcoholic fatty liver disease in non-obese
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent disease and usually related to overweight and obesity, but it affects 10% of the non-obese population in the world and the rates are increasing. Different mechanisms from those traditionally related to excess body fat, such as some genetic polymorphisms and exposure to certain environmental factors, have been associated with the development of this condition.
Metabolic and excretory function is determined mainly by liver activity which can make this organ susceptible to toxic injury, where dysfunction is directly or indirectly mediated by xenobiotics and/or their metabolites. Drug-induced liver disease (DILI) is a rare condition, which is associated with up to 50% of acute liver failure, and hence its importance. Direct injury can be directed to hepatocytes, bile ducts, and vascular structures.
Failure on VOX/VEL/SOF and efficacy of rescue therapy
Retreatment with the combined VOX/VEL/SOF regimen is associated with very high cure rates for hepatitis C. However, it also fails in some patients. In this study, samples from patients in whom retreatment with VOX/VEL/SOF failed were analyzed, and the efficacy of different rescue therapies was evaluated, demonstrating that rescue treatment is effective in the majority of patients (81%).
Agreement between wedged hepatic venous pressure and portal pressure in NASH-related cirrhosis
Portal pressure is generally assessed by measuring hepatic vein wedge pressure due to strong evidence demonstrating its excellent agreement in alcohol- and viral hepatitis cirrhosis. Results from this study show that in patients with decompensated cirrhosis caused by nonalcoholic steatohepatitis, wedge hepatic vein pressure estimates portal pressure less accurately than in patients with other etiologies of cirrhosis, mainly due to underestimation of portal pressure.
Transplantation from HCV-positive donors to HCV-negative donors
According to this multicenter study, grafts from donors exposed to HCV can be safely transplanted into patients who are seronegative for the infection, due to the efficacy of direct-acting antivirals (DAAs). Treatment initiated early post transplantation proved to be effective, achieving a sustained viral response (SVR) in all patients. However, the authors conclude that long-term follow-up in clinical trials is required to confirm these results.